MONOCLE Trial for patients with CMML (Chronic Myelomonocytic Leukaemia) The aim of this study is to assess the effectiveness and safety of a new drug, called Tefinostat, for patients with CMML (Chronic Myelomonocytic Leukaemia). Tefinostat is an oral agent that belongs to a family of drugs called ‘histone deacetylase inhibitors’. Tefinostat only gets converted to its active…
A phase II study of Vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia Results of the research This study, known as the ‘Vorinostat’ trial, was carried out in the UK and Denmark with support from MPN Voice. This support was crucial in getting the trial open and running in the UK. The trial…
We are very keen to support research and trials that ultimately will help MPN specialists understand the complexities and causes of these rare blood cancers so that patients and their families will benefit from better care and more treatment options. Since the formation of MPN Voice we have funded several important studies including the vorinostat…
Recruiting MPN Trials and MPN Trials in ‘Set-up’ Phase The Haematology Research Team at Guy’s Hospital, London, are currently recruiting patients for a number of trials which are now open. There are also a number of trials which are currently in the ‘set-up’ phase. For details of the trials currently recruiting and in the ‘set-up’…
Essential thrombocythaemia (ET) and polycythaemia vera (PV) TAMARIN Effects of TAMoxifen on the Mutant Allele Burden and Disease Course in Patients with Myeloproliferative Neoplasms – ET/PV and MF The TAMARIN study is a very exciting study based on UK science and is now open in 13 hospitals across the UK. The study is a multicentre phase…
Epidemiology There is little information about what causes myeloproliferative neoplasms (MPNs). Patients often ask, “why do I have this disease?”, and for the majority there is no obvious reason. The MOSAICC study (MyelOproliferative neoplasmS: An In-depth Case-Control) is a UK-wide study that aims to identify what causes myeloproliferative neoplasms (MPNs) and the best way to…
You may think that MPN research is primarily focused on investigating new drugs for better blood control in essential thrombocythaemia (ET), myelofibrosis (MF) or polycythaemia vera (PV) and ones that offer patients a longer and better quality of life, indeed eventually hopefully a cure. However there are also a number of projects researching why patients…